MIBG therapy is given to the patient through a central line and enters the bloodstream, where it will go to sites of neuroblastoma throughout the body.  Once the drug is given, the patient becomes radioactive for a period of time.  During this time, the patient must be in a special room in the hospital until radiation levels fall to safe levels.  This usually takes about one week, but can vary from patient to patient. 

Any extra MIBG that is not taken up into neuroblastoma cell is eliminated in the patient’s urine.  Therefore, the patient's urine becomes radioactive for several days and must be managed in a hospital setting.  The MIBG is also released into other bodily fluids.